Maeve Labs
Essential Benefits Evidence Compared Buy

Focus arrived.
Fatigue departed.
Longevity engaged.

Nothing affects healthspan — the part of longevity that matters — the way mitochondria do. Essential™ runs all five stages of their cycle — signal, build, fuel, protect, clear — at the doses the human studies used, in the morning mug you already pour. No assembly required.

Buy
Two hands wrapped around a warm mug of Essential™

The first mug.

Pilot customers, March–August 2026, shared with permission.

"My crushing fatigue was greatly diminished."
Ashley · pilot customer, day one

"Full of energy, good clarity for my writing work, not jittery — and I was super groggy before."

Troy · pilot customer, day one
Jenny's handwritten daily scores for focus, mental energy, clarity and fatigue
Jenny's self-tracked scores, days 1–3 vs. her prior week. Fatigue 8 → 3.

What arrives, and when.

Days 1–7
First to arrive: all-day energy, focus, clarity.
Caffeine + L-theanine, and two fuels for a brain coming off a night’s fast — the mug’s sugar now, MCT as ketones behind it — plus 400 mg rhodiola, which lifts mental work under fatigue from a single dose52, and 9 g creatine, felt within the week53: steady energy through the day, no crash at hour four. The pilot's most consistent day-one report.
Weeks 2–4
Next to lift: the deep fatigue.
Underneath the day-one energy. NAD+ doubles at this dose in fourteen days2, 9 g of creatine finishes loading the brain3 — and rhodiola’s fatigue scores, separated on day one, hold against placebo at two and four weeks16.

"Way more fatigued without it. Those couple weeks I was drinking your coffee daily, I felt amazing."

Pilot customer · two weeks on, one week off
The trials see the same thing: in the one lion’s mane study that kept measuring after dosing stopped, scores fell within four weeks50. This works while you take it.
Months 2–3
Last to arrive: sharper recall.
Growth-factor signalling compounds on a twelve-week clock — long enough for the brain to replace nine-tenths of its mitochondrial proteins41. A protocol, not a pick-me-up.

The full mitochondrial cycle. At clinical doses.

Left to right, the life of a mitochondrion — every day of yours.

The five bodies of the mitochondrial cycle, left to right
Signal
NGF & BDNF
5 mg erinacine A1 · 5 mg erinacine C
10 mg hericenones C+D+E

— place the order to Build.
Assayed for erinacine A by name — the isomer, not “total erinacines”. No mushroom coffee names a standardised active at all17.
Build
NAD+
1,000 mg NMN2 · 20 mg PQQ
1,490 mg TMG

— and the cell fills it.
Fuel
Brain & Body ATP Recharge
9 g creatine3 · 100 mg ubiquinol
— then keep them running.
Oxidative Defense
25 mg ergothioneine
200 mg luteolin

— and they don't burn out.
Protect
Mitophagy
24 mg spermidine
clears overnight

— then start again.
Clear
Each stage, with its evidence →
Signal
NGF & BDNF
5 mg erinacine A1 · 5 mg erinacine C · 10 mg hericenones C+D+E — place the order to Build.
Assayed for erinacine A by name — the isomer, not “total erinacines”. No mushroom coffee names a standardised active at all17.
Build
NAD+
1,000 mg NMN2 · 20 mg PQQ · 1,490 mg TMG — and the cell fills it.
Fuel
ATP recharge
9 g creatine3 · 100 mg ubiquinol — then keep them running.
Protect
Oxidative defense
25 mg ergothioneine · 200 mg luteolin — and they don't burn out.
Clear
Mitophagy
24 mg spermidine · clears overnight — then start again.
Each stage, with its evidence →

Essential is a lot, by design.

That's why it works. It drinks as a heavy mocha leading with cinnamon.

A pilot customer's photo of her mug of Essential™
"This is delicious!" — Jenn, pilot customer

The whole cycle. One price.

Each competitor at its own list price, 28 days at our doses10.

The five stages, bought separately
$343.83
One product per stage, the nearest on the market: ErinaMax, Tru Niagen, MitoQ + Thorne creatine, ergothioneine + luteolin, Timeline. Five subscriptions, five deliveries.
Every row, priced →
Essential™
Essential™ single-serve sachets
$199
All five stages, one mug each morning. One box, 28 sachets.
Arrives monthly · cancel anytime
The coffee
122 mg caffeine, mocha
A moderately strong cup, with L-theanine so it stays smooth and jitter-free.
The mug
253 calories · 5 g sugar
Breakfast-sized. Sugar for the brain now, MCT as ketones alongside it.
The ritual
Instead of your coffee
Sachet, hot water, stir. One a morning — the whole cycle in it.
30 days, guaranteed
Not for you? Full refund.
Cancel anytime
One click. No calls, no counteroffers.
Against a mushroom coffee
Theirs is a gram or two of mushroom, no active named17. Ours is five named mushrooms with every active stated, plus the other four stages. Weighed →
The cycle · 1 / 5
The five stages of the mitochondrial cycle: Signal, Build, Fuel, Protect, Clear
Signal
NGF & BDNF
5 mg erinacine A, from 1 g of assayed mycelium, with erinacine C & hericenones C, D, E — place the order to Build.
Build
NAD+
The NAD+ Triad™ — 1000 mg NMN, with PQQ — and the cell fills it.
Fuel
Brain & Body ATP Recharge
9 g creatine — inside the clinical brain dose range — with MCT and ubiquinol — then keep them running.
Protect
Oxidative Defense
Ergothioneine and luteolin — and they don't burn out.
Clear
Mitophagy
4 steps, clears overnight — then start again.